In-battle, both Sinistra and Destra are identical in terms of stats and abilities, the only difference being their element affiliation: Sinistra is red-affiliated, while Destra is purple-affiliated
Both enemies can use the following battle commands:
Attack: A standard physical attack.
Engage: This ability does nothing, except warn the party that the enemies will use Death Waltz on the next turn.
Death Waltz: Both enemies spin around the party. At the pinnacle of their spin, the two join together and come crashing down, inflicting damage on the party. This ability is only usable if both Sinistra and Destra are present in battle.
Explosion: Used by Sinistra. Sinistra breathes a stream of fire that triggers a fiery explosion, inflicting damage on the party.
Tundra Blast: Used by Destra. Destra breathes a stream of icy cold air, causing the area around the party to freeze over and shatter, inflicting damage on all of them.
The best thing to do is change everyone's weapons to red or purple, depending on the target, and attack one of the heads at a time. Destra and Sinistra's Death Waltz deals a large amount of damage, but can only be used if both of them are in battle. Since both heads are identical in almost every way, it doesn't matter which head is defeated first; the battle will become a lot easier once one of the two has been defeated. The most effective attacks are Vyse's Cutlass Fury and Gilder's Gunslinger, especially if buffed with Increm.